Infectious Diseases Database
"Smarter Diagnosis Starts Here"
About us
IDdx is a clinical decision-support software designed to assist healthcare professionals in diagnosing infectious diseases through intelligent, symptom-based querying. Acting like a searchable, interactive textbook, it allows users to generate and intersect lists of diseases based on specific clinical signs and epidemiological factors for example, identifying infections linked to both abdominal pain and animal bites.
Dengue and Zika Testing for Patients at Risk with Compatible Symptoms
Dengue and Zika are closely related mosquito-borne flaviviruses, sharing similar transmission patterns across tropical and subtropical regions and causing overlapping symptoms such as fever, rash, myalgia, and arthralgia. For patients suspected of having either infection, nucleic acid amplification tests (NAATs) are the preferred diagnostic approach. While IgM antibody tests can help detect additional cases, interpreting results can be challenging due to cross-reactivity and uncertainty in pinpointing the exact timing of infection.
These challenges are particularly significant in pregnant individuals, where distinguishing whether a Zika infection occurred during pregnancy is crucial. This summary outlines updated CDC guidance for diagnostic testing in patients presenting with clinically compatible illness and recent exposure in areas with known circulation of both pathogens. Recommendations for screening asymptomatic pregnant women remain unchanged. For symptomatic nonpregnant individuals, NAATs should be performed on serum samples collected within 7 days of symptom onset.
Evaluating Alpha-Defensin Accuracy for Diagnosing Periprosthetic Joint Infection in Patients with Inflammatory Diseases
The alpha-defensin take a look at has been reported to have excessive accuracy to diagnose periprosthetic joint an infection (PJI). There are remaining considerations in regards to the utility of the take a look at in sufferers with inflammatory illnesses.
Instances with inflammatory illnesses who acquired a 1-stage revision arthroplasty, the primary stage of 2-stage revision arthroplasty, or irrigation and debridement with accessible preoperative alpha-defensin outcomes had been included. Sufferers who acquired a second-stage process, spacer alternate, who had inadequate Musculoskeletal An infection Society standards, or with early postoperative PJI had been excluded from this research. Instances had been categorised as contaminated or not in response to Musculoskeletal An infection Society standards. A complete of 41 instances met the inclusion standards.
Diagnostic and therapeutic strategy to infectious illnesses in strong organ transplant recipients.
Prognosis of strong organ transplant (SOT) recipients has improved, primarily due to higher prevention of rejection by immunosuppressive therapies. Nevertheless, SOT recipients are extremely inclined to standard and opportunistic infections, which symbolize a significant reason for morbidity, graft dysfunction and mortality.Narrative evaluate.We cowl the present epidemiology and primary facets of infections in SOT recipients together with danger components equivalent to postoperative dangers and particular dangers for various transplant recipients, key factors on anti-infective prophylaxis in addition to diagnostic and therapeutic approaches.
We offer an up-to-date information for administration of the primary syndromes that may be encountered in SOT recipients together with acute respiratory failure, sepsis or septic shock, and central nervous system infections in addition to bacterial infections with multidrug-resistant strains, invasive fungal illnesses, viral infections and fewer frequent pathogens which will affect this affected person inhabitants.We offer state-of the artwork evaluate of accessible data of critically unwell SOT sufferers with infections.
Early Markers of Dengue and Plasma Leakage in Adults
A prospective cohort study of clinically suspected adult dengue patients recruited within the first three days of fever aimed to: a) identify clinical and basic laboratory parameters to distinguish dengue from non-dengue fever; b) evaluate the comparative efficacy of loop-mediated isothermal amplification (LAMP) for dengue diagnosis versus NS1 antigen test and RT-qPCR; and c) identify early markers predictive of plasma leakage or severe dengue. The basic laboratory tests considered included hematological parameters, serum biochemistry, and inflammatory markers.
Only about 70% of clinically suspected patients were confirmed as having dengue by either NS1 antigen test or RT-qPCR. Using a Bayesian latent class model assuming no “gold standard,” LAMP performed equally or better than RT-qPCR and NS1 antigen test, respectively.
When confirmed dengue patients were compared with others, the former group had significantly lower lymphocyte counts and higher aspartate aminotransferase (AST) levels within the first three days of fever. Confirmed dengue patients who developed plasma leakage were younger on average and had higher baseline AST levels compared to those without plasma leakage (p < 0.05).
Clinical suspicion tends to overestimate the true number of dengue cases. RT-LAMP is a promising, low-cost diagnostic tool for dengue detection. Confirmed dengue patients showed higher early AST levels and lower lymphocyte counts compared to others. Among confirmed cases, younger age and higher AST levels early in infection were associated with subsequent plasma leakage.
IDx: Infectious Disease Queries
Decision-Support Software for Infectious Diseases
The ability to limit the differential diagnosis list by incubation period was added in 2012. There are seven options beginning with 0-6 hours and ending with >2 years. Infectious diseases have a range for the incubation, and I use the data in CCDM if available. For diptheria, it is 2-5 days, so both 24-48 hours and 2-14 days are checked. For botulism, it is 12-36 hours, but may be several days after eating contaminated food and 4-17 days after a wound infection, so 3 of the 7 options are checked. Most infectious diseases have a range that encompasses more than one of the seven incubation periods in IDdx. One strategy would be to try your query with more than one period (Match Any or OR query) selected to see if this changes your results.
To limit the differential diagnosis,
Put one or more epidemiological factors in your query.
Entry
- Animal Bite: Infected by Animal Bite
- Ingest: Infected by Ingestion
- Inhale: Infected by Inhalation
- Needle: Infected by Needle (Includes Drug Abuse), Scalpel, or Transfusion
- Sex: Infected by Sexual Contact
- Skin/Eye: Infected through Skin or Mucous Membranes (Includes Conjunctiva)
- Swim: Infected while Swimming
Source
- Dairy: Eating Unpasteurized Milk or Cheese
- Edible Plant: Eating Contaminated Produce
- Excreta: Animal Excreta
- Fecal-Oral: Human Fecal-Oral Transmission
- Fecal-Soil: Fecal-Contaminated Soil (Animal or Human)
- Food: Eating Contaminated Food
- Meat: Eating Contaminated or Infected Meat
- Patient: Person-to-Person Transmission
- Seafood-Fish: Eating Infected or Toxin-Containing Fish
- Seafood-Shellfish: Eating Contaminated Mollusks or Crustacean (Oyster, Shrimp, or Lobster)
- Soil: Soil or Dust (Ingesting or Inhaling)
- Tissue: Animal Tissue
- Water: Waterborne (Ingesting, Inhaling, or Swimming)
4 clear and effective steps to protect yourself from mosquito bites
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Wear Light-Colored, Long Clothing
🔹 Mosquitoes are attracted to dark colors.
🔹 Cover your arms and legs, especially during dawn and dusk when they’re most active.
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2. Use Mosquito Repellent
🔹 Apply repellent with DEET, picaridin, or lemon eucalyptus oil.
🔹 Reapply as recommended on the label for lasting protection.
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3. Sleep Under Mosquito Nets
🔹 Use bed nets, window screens, and door screens to block mosquitoes.
🔹 Especially important in tropical or high-risk areas.
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4. Remove Standing Water
🔹 Empty flower pots, buckets, and old tires anywhere water collects.
🔹 Mosquitoes lay eggs in stagnant water, so remove breeding grounds.